HISTOPATHOLOGY

Toxicologic pathologists play an increasingly important role in product development and often act as Study Directors for compounds under development as pharmaceutical and chemical agents.

Pathologists need a visible morphological change to detect when a disruption of homeostasis occurs regardless to whether the cause of cell injury is toxic or not, and regardless of the biochemical events that caused the injury or death of the cell.

The lesion, whether ultrastructural, microscopic or macroscopic, is this visible manifestation. It allows toxicologic pathologists to reach a diagnosis, which should ideally include the etiology and a description of the underlying morphologic alterations.

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Examples

histopathology

Rat

Background lesion in Wistar Rat. Lung. Vascular mineralization. Obj. 10x.

histopathology

Dog

Induced lesion in Beagle Dog. Lung. Bronchitis / Bronchiolisis with foreign bodies. Obj. 10x.

histopathology

Rat

Induced lesion in Wistar Rat. Kidneys. Papillary necrosis. Obj. 4x.

histopathology

Monkey

Background lesion in Cynomolgus monkey. Cecum. Balantidium Coli in the lumen. Obj. 40x.

histopathology

Monkey

Induced lesion in Cynomolgus monkey. Mammary gland. Ductal Ectasia / Increased glandular secretion. Obj. 4x.