Toxicologic pathologists play an increasingly important role in product development and often act as Study Directors for compounds under development as pharmaceutical and chemical agents.
Pathologists need a visible morphological change to detect when a disruption of homeostasis occurs regardless to whether the cause of cell injury is toxic or not, and regardless of the biochemical events that caused the injury or death of the cell.
The lesion, whether ultrastructural, microscopic or macroscopic, is this visible manifestation. It allows toxicologic pathologists to reach a diagnosis, which should ideally include the etiology and a description of the underlying morphologic alterations.
Background lesion in Wistar Rat. Lung. Vascular mineralization. Obj. 10x.
Induced lesion in Beagle Dog. Lung. Bronchitis / Bronchiolisis with foreign bodies. Obj. 10x.
Induced lesion in Wistar Rat. Kidneys. Papillary necrosis. Obj. 4x.
Background lesion in Cynomolgus monkey. Cecum. Balantidium Coli in the lumen. Obj. 40x.
Induced lesion in Cynomolgus monkey. Mammary gland. Ductal Ectasia / Increased glandular secretion. Obj. 4x.